Skip to main content

Table 2 Prnp genotype frequencies [%] of scrapie cases and control goats.

From: Caprine prion gene polymorphisms are associated with decreased incidence of classical scrapie in goat herds in the United Kingdom

Herd

Genotype

A

Gp1

Scr+

A

Gp2

Scr+

B

Gp1

Scr+

B

Gp2

Scr+

A

Gp1/2

Scr+

B

Gp1/2

Scr+

E

Scr+

B

Scr-

A&

Scr-

A$

cl. Scr-

E*

cl.

Scr-

wt-S/wt-S

6

3

0

0

4.6

0

0

0

2.3

6.6

0

wt-P/wt-S

34.8

12.3

11.1

0

23.7

6.3

66.7

1.3

4.6

21.7

12

wt-P/wt-P

43.9

21.5

77.8

57.1

32.8

68.7

33.3

24.6

12.5

21.2

22

wt-P/S127

1.5

4.6

11.1

42.9

3.1

25

0

28.3

8.6

6

3.3

wt-S/S127

0

7.7

0

0

3.9

0

0

1.9

0.8

2

0

S127/S127

0

0

0

0

0

0

0

5

0

0

0

S127/M142

0

1.6

0

0

0.8

0

0

11.9

2.3

3

3.3

wt-P/M142

10.6

29.3

0

0

19.7

0

0

20.1

30.5

19.7

31.9

wt-S/M142

1.6

15.4

0

0

8.4

0

0

0.6

16.4

7

7.7

M142/M142

0

3

0

0

1.5

0

0

5

17.2

7.6

9.9

R101 carrier

0

0

0

0

0

0

0

1.2

0

0

0

Q211 carrier

0

0

0

0

0

0

0

0

3.2

2.5

3.4

K222 carrier

0

0

0

0

0

0

0

0

0.8

1

5.5

Partial^

1.6

1.6

0

0

1.6

0

0

0

0.8

1.6

1.1

Total (n)

66

65

9

7

131

16

3

159

128

198

91

  1. Legend: For allele abbreviation see Figure 1. Scr = scrapie; cl = clinical; for definition of group-1 (Gp1) and group-2 (Gp2) see main text, in short: group-1 clinical positive and fallen stock goats, group-2 pre-clinical, PrPd positive goats; Gp1/2 = Gp1+Gp2; ^partial here means one allele in heterozygote could not be unambiguously identified for all positions; &scrapie-free goats, clinically and PrPd negative; $clinically negative goats, randomly selected goats of which approx. 1/3 were tested and found negative for PrPd; *randomly selected clinically negative herd-mates, not tested for PrPd.