Modification of PCV-2 virulence by substitution of the genogroup motif of the capsid protein

Table 2 Score means of the macrolesions observed for the tracheobronchial (TB) lymph nodes and of the microlesions observed for in TB and inguinal lymph nodes and lungs

Groups	Number of animals presenting TB lymph node lesions and score means	Score means of the microlesions
Group 1: Control	0/4 0 ^a	0 ^a
Group 2: Control + immunostimulation	¾ 0.625 ^a	0.625 ^a
Group 3: PCV2-a + immunostimulation	8/8 1.375 ^b	1.125 ^b
Group 4: PCV2-b + immunostimulation	8/8 1.5 ^b	1.5 ^b
Group 5: PCV-2a/motif 2b + immunostimulation	4/8 0.625 ^a	1.09 ^b
Group 6: PCV-2b/motif 2a + immunostimulation	6/8 0.875 ^{a, b}	1.34 ^b

Macrolesions in TB lymph nodes were scored as follows: 0 for no lesions, 1 for mild hypertrophy, 2 for moderate hypertrophy and congestion and 3 for severe hypertrophy and congestion. In the same way, microscopic lesions observed in lymphoid organs (lymphocyte depletion in TB and inguinal lymph nodes) and in lungs (interstitial pneumonia) were scored. Score means were then calculated and subjected to statistical analysis, with a and b indicating statistic difference (^a and ^b for p < 0.05).

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