Figure 1From: High interferon type I responses in the lung, plasma and spleen during highly pathogenic H5N1 infection of chickenH5N1 AIV induce IFN in chicken splenocytes. Splenocytes were stimulated with various doses of AIV for 24 h. In (A), live and BEI-inactivated Vac and Yama viruses are shown. In (B), Vac and Yama are compared with the reassortants Vac-Y/HA and Yama-V/HA. In (C), various natural isolates of LPAIV and HPAIV are shown. IFN was quantified by bioassay. The averages of triplicate cultures with standard deviations are shown. The * indicates statistical differences calculated with the students t-test (p < 0.05). The results are representative for at least three independent experiments.Back to article page