From: The current status and future directions of myxoma virus, a master in immune evasion
ORF | Protein name | Function | references |
---|---|---|---|
M002R/L | M-T2 | TNFR homolog; inhibits TNF/TNFR; prevents apoptosis of lymphocytes intracellularly | |
M11L | Â | Binds with Bak and/or Bax; inhibits apoptosis | |
M146R | Â | Postulated to bind Bcl-2 proteins and inhibit TLR-mediated innate responses | |
M005R/L | M-T5 | Enhances degradation of CDK inhibitors; prevents checkpoint-induced apoptosis | |
M150R | MNF | ANK-repeat protein; inhibits NF-κB | |
M148R | Â | ANK-repeat virulence factor, but no specific function defined to date | [49] |
M149R | Â | ANK-repeat virulence factor, but no specific function defined to date | [49] |
M153R | MV-LAP | Downregulates cell surface CD4, Fas-CD95 and MHC-1 | |
M143 | Â | Ubiquitin ligase with a possible anti-apoptotic function | [1] |
M004R/L | M-T4 | Possible interference with BAP31 in the ER; apoptosis inhibitor | |
M156R | Â | PKR pseudosubstrate and inhibitor | |
M029L | Â | Predicted inhibitor of PKR via dsRNA binding | [1] |
M062R | Â | Host range factor essential for replication in rabbit or human cancer cells; binds SAMD9 | |
M063R | Â | Host range factor, essential for replication in rabbit cells | |
M064R | Â | Related to M062 and M064 host range factors but function not yet determined | |
M001R/L | M-T1 | CC-chemokine binding protein | |
M104L | Â | Postulated inhibitor of chemokine receptor signaling | [1] |
M007R/L | M-T7 | Secreted inhibitor of IFN-γ and chemokines; anti-inflammatory activities | [69] |
M008R/L | Serp-1 | Secreted serpin that inhibits diverse host serine proteases; anti-inflammatory activities | |
M151R | Serp-2 | Intracellular serpin that inhibits ICE and granzyme B | |
M152R | Serp-3 | Serpin and virulence factor, but no specific host target yet described | [74] |
M141R | vCD200 | Cell surface virulence factor that inhibits CD200R+ leukocytes (also called vOX-2) | |
M121R/M122R | Â | Predicted NK regulatory receptor homologs | [1] |
M128L | vCD47 | Cell surface virulence factor and CD47 homolog | |
M13L |  | Pyrin-containing protein that inhibits the inflammasomes and NF-κB signaling | |
M129R | Â | Predicted HIV gp120 homolog, but function still unknown | [60] |
M130R | Â | Predicted HIV Tat homolog; virulence factor | |
M010L | MGF | Secreted virulence factor, related to TGFalpha and EGF | [89] |
M135R | Â | B19R (VACV) homolog, virulence factor, but no specific function or ligand known | |
M144R | Â | C3L/B5R (VACV) homolog, no confirmed function yet | [60] |