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Table 3 Clinically adapted MYXV proteins for treating inflammatory diseases.

From: The current status and future directions of myxoma virus, a master in immune evasion

Gene product

Potential clinical use

References

Serp-1

Secreted serpin that effectively inhibits vascular inflammatory responses and has been tested in human clinical trials to treat acute coronary syndrome.

[122–125]

Serp-2

Viral anti-apoptotic serpin effective in animal models but not yet tested in humans.

[19]

M-T1

Chemokine inhibitor that reduces the allograft rejection and stabilizes plaque formation during artherosclerosis.

[127–129]

M-T7

Chemokine inhibitor that attenuates systemic inflammatory responses and inhibits leukocyte infiltration, thus preventing transplant rejection.

[126–129]

M-T2

TNF/TNFR inhibitor but not yet tested as a potential therapeutic.

[28, 30, 129]

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Veterinary Research

ISSN: 1297-9716