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Table 3 Immunohistochemical and western blot analyses of PrPSc in tissue samples obtained from cattle intracerebrally challenged with H-type BSE

From: Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits

Tissue

Case code

 

7749

9458

0728

 

IHC

WB

IHC

WB

IHC

WB

Central nervous system

      

   Cerebral cortex

+

+

+

+

+

+

   Obex

+

+

+

+

+

+

   Cerebrum

+

+

+

+

+

+

   Spinal cord

+

+

+

+

+

+

Peripheral nervous system

      

   Cauda equina

+

+

+

+

+

+

   Dorsal root ganglia

+

+

+

+

+

+

   Trigeminal ganglia

+

+

+

+

+

+

   Cranial cervical ganglia

-

+

-

+

-

+

   Stellate ganglia

-

+

-

+

-

+

   Sympathetic trunk

-

+

-

+

-

+

   Celiac-mesenteric ganglion complex

-

+

-

+

-

+

   Vagus nerve

-

+

-

+

-

+

   Facial nerve

-

+

-

+

-

-

   Hypoglossal nerve

-

+

-

+

-

-

   Phrenic nerve

-

+

-

+

-

+

   Accessory nerve

-

-

-

+

-

+

   Suprascapular nerve

-

+

-

+

-

+

   Brachial plexus

-

+

-

+

-

+

   Median nerve

-

+

-

+

-

+

   Radial nerve

-

+

-

+

-

+

   Sciatic nerve

-

+

-

+

-

+

   Tibial nerve

-

+

-

+

-

+

   Optic nerve

+

+

+

+

+

+

   Retina

+

+

+

+

+

+

   Pituitary gland

+

+

+

+

+

+

   Adrenal gland

-

+

-

+

-

+

Lymphoid tissues

      

   Spleen

-

-

-

-

-

-

   Tonsils (palatine, pharyngeal, lingual)

-

-

-

-

-

-

   Thymus

-

-

-

-

-

-

   Parotid lymph node

-

-

-

-

-

-

   Mandibular lymph node

-

-

-

-

-

-

   Lateral retropharyngeal lymph node

-

-

-

-

-

-

   Superficial cervical lymph node

-

-

-

-

-

-

   Brachiocephalic lymph node

-

-

-

-

-

-

   Axillary lymph node

-

-

-

-

-

-

   Superficial inguinal lymph node

-

-

-

-

-

-

   Subiliac lymph node

-

-

-

-

-

-

   Popliteal lymph node

-

-

-

-

-

-

   Hepatic lymph node

-

-

-

-

-

-

   Internal iliac lymph node

-

-

-

-

-

-

   External iliac lymph node

-

-

-

-

-

-

   Mesenteric lymph node

-

-

-

-

-

-

  1. IHC, immunohistochemistry; WB, western blotting; +, positive for PrPSc; -, negative for PrPSc