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Table 2 Antimicrobial activities and characteristics of equine antimicrobial peptides

From: Antimicrobial peptides and proteins of the horse - insights into a well-armed organism

Peptide family

Peptide

Mass [kDa]

Charge

(at pH 7.5)

Specificity

Salt

dependency

Citation

Cathelicidins

     

eCATH-1

[GenBank: CAA12226]

3.1

8.8

Gram-positive/negative bacteria

Fungi

no

no

[35, 111]

eCATH-2

[GenBank: CAA12227]

3.6

2.8

Gram-positive/negative bacteria

Fungi

no

yes

[35, 111]

eCATH-3

[GenBank: CAA12228]

4.7

7.0

Gram-positive/negative bacteria

Fungi

yes

yes

[35, 111]

eCATH-4

[GenBank: XP_001495199.2]

n. d.

n. d.

n. d.

 

this review

EA-CATH-1

[GenBank: ACN93988.1]

3.1

6.8

Gram-positive/negative bacteria

Fungi

no

no

[43]

Defensins

     

DEFB1

[GenBank: AAO32801]

4.0

5.2

n. d.

 

[36]

DEFL2

[GenBank: CAJ01792]

4.5

6.5

n. d.

 

[40, 145]

DEFL3

[GenBank: CAJ01793]

4.2

5.6

n. d.

 

[40, 145]

DEFB103

[GenBank: CAJ01801]

4.7

9.2

n.d.

 

[40, 145]

DEFA1

[GenBank: ABP96800]

4.1

6.3

Gram-positive/negative bacteria

Yeast

yes

yes

[40–42, 131]

DEFA2 to 29

[GenBank: ACV49728-ACV49755]

3.6 - 5.5

2.3 - 9.2

n. d.

 

[41]

Neutrophil antimicrobial peptides

     

eNAP-1

[GenBank: AAB22706]

7.2

n. d.

Gram-positive/negative bacteria

n. d.

[33]

eNAP-2

[GenBank: AAB24353]

6.5

n. d.

Gram-positive/negative bacteria

n. d.

[32, 34]

Lysozymes

     

Equine lysozyme

[Swiss-Prot: P11376]

14.7

2.2

Gram-positive/negative bacteria

n. d.

[46–48, 50]

NK-lysins

     

Equine NK-lysin

[GenBank: AAN10122]

9.2

7.2

n. d.

 

[37, 82]

Psoriasin (S100A7)

     

Psoriasin 1

[GenBank: CAH03717]

11.3

-6.2

Escherichia coli

n.d.

[39, 100]

Hepcidin

     

Equine hepcidin

[GenBank: XM_001491610.2]

2.8

1.1

n. d.

 

[158]

  1. Peptide masses and charges that have not been determined experimentally were complemented using the ProteinCalculator v3.3 software [193].