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Table 1 Susceptibility of some mouse strains used as models of non-pregnancy-associated L. monocytogenes infection, measured as median lethal dose (LD50)

From: Animal models of listeriosis: a comparative review of the current state of the art and lessons learned

mouse strain

LD50range (in CFU) reported in the literature

Recognized mouse phenotype

 

oral/intragastric

intravenous

 

intraperitonial

  
 

LD 50 (strain)

Reference

LD 50 (strain)

Reference

LD 50 (strain)

Reference

 

A/J

106(a)

[137]

103(b, d)

[138, 141]

< 107- 1011(b, d,e, i)

[142, 143]

susceptible

A/Tru × C57Bl/67

  

104(b)

[144]

  

-

A/Tru × C57Bl/64

  

106(b)

[144]

  

-

A/Tru × C57Bl/68

  

105(b)

[144]

  

-

A/WySn

  

104(d)

[138]

  

-

BALB/c

  

103(b, d)

[138, 145]

105(i)

[147]

susceptible

   

104(c)

[146]

   
   

105(f, i)

[139]

   

B10.A

  

105(b,d)

[138, 141]

  

resistant

B10.D2/Sn

  

105(b, d)

[138, 141]

  

resistant

CBA

  

103(d)

[138]

  

susceptible

C3HeB/FeJ

    

104(i)

[148]

susceptible

C57BL/6

103(b)

[145]

103(b)

[145]

  

resistant

 

108(a)

[137]

105(b)

[149]

   
 

> 1010(b)

[149]

106(d, f, i)

[138, 139]

   

C57BL/6 × BALB/c

  

103(b)

[42]

  

intermediate

   

104(d)

[138]

   

C57BL/6 × DBA/2 N

  

104(b)

[150]

107- 109(b, e, i)

[143]

intermediate

C57BL/10Sn

  

105(b)

[141]

  

resistant

DBA/2 J

  

103(b)

[141]

  

susceptible

ddY3

104(g)

[127]

    

-

ddY4

>109(g)

[127]

    

-

ICR

  

105(d)

[151]

104- 107(a,d,e,i)

[152]

intermediate

     

104- >108(b,d,i)

[19, 153]

 
     

105- >109(a,d,e,i)

[154]

 

Inbred white (Washington State University)

    

105- 107(c)

[155]

-

NCR1

101- 105(d, e, i)

[17]

  

101- 105(d, e)

[17]

-

NCR

103- 106(d, e,i)

[17]

  

102- 106(d, e,i)

[17]

-

NMRI5

  

104(f)

[156, 157]

10 4 - 10 12

[158]

-

   

104- 1012(f,g,h,i)

[158]

(f,g,h,i)

  

Swiss

  

105(b)

[159]

  

-

Swiss-Webster

    

101- 105(i)

[115]

-

     

105- 107(c)

[155]

 

Swiss white

    

107(a,d,e)

[18]

-

Porton

>1010(b,d,e,i)

[160]

    

-

129 Sv × C57BL/6

    

104(b)

[161]

intermediate

iFABP-hEcad2

~1010(b)

[149]

    

transgenic

E16PmEcad6

n/a

     

transgenic

  1. Animals represent non-pregnant adults unless stated otherwise.
  2. 1body weights ranging from 10 - 20 grams; 2(C57BL/6 J × SJL/J) background; 3suckling mice; 4adult mice; 5derived from swiss-type mouse; 6only competitive indexing experiments performed; 7juvenile mice; 8geriatric mice
  3. L. monocytogenes strains:
  4. (a) L.monocytogenes Scott A (serotype 4b); (b) L.monocytogenes EGD (serotype 1/2a); (c) L. monocytogenes 10403S (serotype 1/2a); (d) human clinical isolate; (e) food isolate; (f) L. monocytogenes 4b isolate; (g) L. monocytogenes 1b isolate; (h) L. monocytogenes 3a isolate; (i) other or not specified L. monocytogenes isolate.