Gene symbol | Gene name | Gene description | 2 h mean fold-changes in gene expression | 6 h mean fold-changes in gene expression | 24 h mean fold-changes in gene expression | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Microarray data | Real time qRT-PCR | P-value (real time qRT-PCR) | Microarray data | Real time qRT-PCR | P-value (real time qRT-PCR) | Microarray data | Real time qRT-PCR | P-value (real time qRT-PCR) | |||
AREGB | Amphiregulin B | A growth-modulating glycoprotein | NS | - 1.29 | ≤ 0.01 | - 2.03 | - 2.58 | ≤ 0.05 | NS | - 1.54 | ≤ 0.01 |
CCL4 | Chemokine (C-C motif) ligand 4 | A proinflammatory and chemotactic chemokine | + 6.59 | + 28.87 | ≤ 0.001 | + 3.11 | + 9.67 | ≤ 0.05 | NS | + 1.28 | NS |
CCL5 | Chemokine (C-C motif) ligand 5 | A proinflammatory chemokine involved in the chemotaxis of monocytes and T-helper cells | + 3.56 | + 5.07 | ≤ 0.05 | + 4.02 | + 4.60 | ≤ 0.05 | NS | + 2.11 | ≤ 0.05 |
CCL20 | Chemokine (C-C motif) ligand 20 | A chemokine involved in the chemoattraction of lymphocytes and neutrophils | + 10.47 | + 63.19 | ≤ 0.001 | + 2.80 | + 10.82 | ≤ 0.05 | NS | + 1.22 | NS |
CD40 | CD40 molecule, TNF receptor superfamily member 5 | A member of the TNF-receptor superfamily. Mediates the immune and inflammatory responses | + 4.44 | + 6.55 | ≤ 0.001 | + 5.23 | + 10.80 | ≤ 0.001 | + 1.71 | + 1.82 | ≤ 0.05 |
CFB | Complement factor B | A component of the alternative pathway of complement activation | + 3.54 | + 4.61 | ≤ 0.05 | + 4.84 | + 8.64 | ≤ 0.01 | + 2.98 | + 4.19 | ≤ 0.001 |
CXCL2 | Chemokine (C-X-C motif) ligand 2 | An immunoregulatory chemokine produced by activated monocytes and neutrophils at sites of inflammation | + 14.34 | + 28.56 | ≤ 0.001 | + 2.38 | + 3.07 | ≤ 0.01 | NS | + 1.45 | NS |
IL1B | Interleukin 1, beta | A cytokine that mediates the inflammatory response including cell proliferation, differentiation and apoptosis | + 14.41 | + 48.53 | ≤ 0.001 | + 2.97 | + 6.16 | ≤ 0.05 | NS | + 2.25 | ≤ 0.05 |
IL6 | Interleukin 6 | A cytokine that functions in inflammation and the maturation of B cells | + 6.25 | + 21.12 | ≤ 0.001 | NS | + 2.51 | ≤ 0.01 | NS | + 1.38 | NS |
IL15 | Interleukin 15 | A cytokine that regulates T and natural killer cell activation and proliferation | + 3.51 | + 4.40 | ≤ 0.001 | + 2.03 | + 2.73 | ≤ 0.01 | NS | 1.04 | NS |
IRF1 | Interferon regulatory factor 1 | A member of the interferon regulatory transcription factor family. An activator of interferon alpha and beta transcription | + 6.57 | + 12.64 | ≤ 0.001 | + 3.60 | + 5.20 | ≤ 0.01 | NS | + 1.60 | ≤ 0.01 |
NFKB2 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | A pleiotropic transcription factor involved in inflammation, immunity, differentiation, cell growth and apoptosis | + 3.41 | + 5.37 | ≤ 0.001 | + 3.69 | + 5.82 | ≤ 0.001 | NS | + 1.34 | NS |
PIK3IP1 | Phosphoinositide-3-kinase interacting protein 1 | Suppresses the activity of phosphatidylinositol-3-kinase (PI3K), a regulator of cell division | - 1.70 | - 2.34 | ≤ 0.05 | NS | - 1.36 | NS | NS | + 1.54 | NS |
SPRY2 | Sprouty homolog 2 (Drosophila) | An inhibitor of receptor tyrosine kinase signalling proteins | - 2.07 | - 2.20 | NS | NS | - 1.12 | NS | NS | - 1.46 | NS |
TNF | Tumor necrosis factor (TNF superfamily, member 2) | A proinflammatory cytokine (secreted by macrophages) involved in the regulation cell proliferation, differentiation and apoptosis, and coagulation. | + 13.89 | + 33.01 | ≤ 0.001 | + 2.73 | + 6.51 | ≤ 0.01 | NS | + 1.61 | ≤ 0.01 |