What have we learned from brucellosis in the mouse model?

Grilló, María-Jesús; Blasco, José María; Gorvel, Jean Pierre; Moriyón, Ignacio; Moreno, Edgardo

doi:10.1186/1297-9716-43-29

Veterinary Research

Table 1 Replication and persistence of smooth virulent Brucella in mutant and knockout mice strains

From: What have we learned from brucellosis in the mouse model?

Test mouse strain	Phenotypic defect	Reference mouse strain	Brucella spleen CFU increase and persistence relative to mouse reference strain^a		References
Test mouse strain	Phenotypic defect	Reference mouse strain	Early before 14 days	Late after 15 days	References
CBA/H	Inbred no specific defect	BALB/c	↓	↑	[39]
CBA/H	Inbred no specific defect	C57BL/10	↑	↑	[39]
CBA/NJ	Inbred no specific defect	BALB/c	↔	↔	[40]
DBA2	Inbred no specific defect	C57BL/6	↑	↑	[41, 42]
CD-1	Outbreed Swiss mice	BALB/c	↔	↔	[40]
BALB/c	Inbred no specific defect	C3H/HeN	↔	↔	[40]
BALB/c	Inbred no specific defect	C57BL/6	↑	↑	[39]
BALB/c	Inbred no specific defect	C57BL/10	↑	↑	[39]
BALB/c	Inbred no specific defect	C.CB (Nramp1r)	↓	↔	[43]
C57BL/10	Inbred no specific defect	B10Br	↔	↔	[39]
C57BL/6 (TLR9)	CpG motifs recognition	C57BL/6	↑	↑	[44, 45]
BALB/c (TLR9)	CpG motifs recognition	BALB/c	↔	↔	[46]
BALB/c (TLR4)	LPS detection	BALB/c	↔	↔	[46]
BALB/c (TLR4)	LPS detection	BALB/c	↑	↔	[44]
C3H/HeJ (TLR4)	LPS detection	C3H/HePas	↑	↑	[47]
C3H/HeJ (TLR4)	LPS detection	C3H/HeAu	↔	↔	[48]
C3H/HeJ (TLR4)	LPS detection	C3H/Heb	↔	↔	[41, 42]
C3H/HeJ (TLR4)	LPS detection	C3H/HeN	↔	↔	[40, 49]
C3H/HeJ (TLR4)	LPS detection	BALB/c	↔	↔	[40]
C57BL/6 (TLR4)	LPS detection	C57BL/6	↔	↔	[50]
C57BL/6 (TLR2)	Lipoproteins detection and peptidoglycan detection	C57BL/6	↔	↔	[47, 50]
BALB/c (TLR2)	Lipoproteins detection and peptidoglycan detection	BALB/c	↔	↑	[46]
BALB/c (TLR2)	Lipoproteins detection and peptidoglycan detection	BALB/c	↔	↔	[44]
C57BL/6 (TLR2/4)	LPS and lipoproteins detection	C57BL/6	↔	↔	[50]
BALB/c (TLR2/4)	LPS and lipoproteins detection	BALB/c	↑	↔	[44]
C57BL/6 (NOD1)	muramyl peptides meso-diaminopimelic acid	C57BL/6	↔	ND	[51]
C57BL/6 (NOD2)	muramyl dipeptides	C57BL/6	↔	ND	[51]
C57BL/6 (Myd88)	Low proinflammatory response	C57BL/6	↑	↑	[44, 45, 50]
C57BL/6 (TRIF)	Low proinflammatory response	C57BL/6	↔	↔	[44]
C57BL/6 (TRIF)	Low proinflammatory response	129 Sv/Ev	ND	↔	[44]
C57BL/10 (IRAK-4)	Low proinflammatory response	C57BL/6	↑	↔	[52]
C57BL/6 (Rip2)	NOD adaptor protein	C57BL/6	↔	ND	[51]
C57BL/6 (gp91^phox)	Low respiratory burst in phagocytes	C57BL/6	↔	↑	[53]
C57BL/6 (iNOS)	Low respiratory burst in phagocyte	C57BL/6	↑	↑	[44]
C57BL/6 (iNOS)	Low respiratory burst in phagocytes	C57BL/6	↔	↑	[53]
C57BL/6 (IL-12p40)	Early differentiation of Th1 cells	C57BL/6	↔	↑	[53]
DBA/2j xC57BL/6 (iNOS/IL-12p40)	Early differentiation of Th1 cells and low respiratory burst	DBA/2j xC57BL/6	↔	↑	[53]
DBA/2 J (ICSBP)	Deficient in IL-12p40 and low respiratory burst	C57BL/6	↑	↑	[53]
C57BL/6 xDBA/2 J (iNOS/ICSBP)	Deficient in IL-12p40 and low respiratory burst	C57BL/6 xDBA/2 J	↑	↑	[53]
C57BL/6 (IRF-2)	Deficient in NK cells and dysregulation of IL-12p40	C57BL/6	↓	↔	[53]
C57BL/6 (igh6)	Affects B cells	C57BL/6	↔	↔/↓	[54]
C57BL/6 (igh6)	Affects B cells	C57BL/6	↓	↓	[55]
BALB/c (jh)	Affects B cells	BALB/c	↓	↓	[55]
C57BL/6 (rag-1)	Affects B and T cells	C57BL/6	↔	↔	[54]
C57BL/6 (Cd4)	Affects CD4 T cells	C57BL/6	↔	↓	[54]
C57BL/6 (Aβ)	Affects CD4 T cells	C57BL/6	↓	↔	[56]
C57BL/6 (Aβ)	Affects CD4 T cells	C57BL/6	↔	↔	[55]
C57BL/6 (Pfp)	Affects Restriction of Tc mediated killing	C57BL/6	↑	↔	[57]
C57BL/6 (β2m)	Affects CD8 T cells	C57BL/6	↑	↑	[56]
C57BL/6 (β2m)	Affects CD8 T cells	C57BL/6	↔	↔	[54]
C57BL/6 (β2m)	Affects CD8 T cells	C57BL/6	↑	↔	[57]
C57BL/6 (β2m)	Affects CD8 T cells	C57BL/6	↔	↓	[55]
C57BL/6 (IL12/β2m)	Affects CD8 T cells and early differentiation of Th1 cells	C57BL/6	↑	↑	[58]
C57BL/6 (nu/nu)	Lack thymus derived T cells	C57BL/6	↓	↑	[59]
BALB/c (ifng)	Absence of IFN-γ	BALB/c	↔	↑ Dead	[57]
C57BL/6 (ifng)	Absence of IFN-γ production	C57BL/6	↑	↑	[44, 54, 58]
C57BL/6 (ifng)	Absence of IFN-γ production	C57BL/6	↔	↑ Dead	[57]
C57BL/6 (ifng)	Absence of IFN-γ production	C57BL/6	↔	↑	[55]
C57BL/6 (ifng)	Absence of IFN-γ production	C57BL/6	↑	ND	[60]
C57BL/6 (IRF-1)	CD8 T and NK cells dysregulation of IL-12p40 low respiratory burst	C57BL/6	↑	↑ Dead	[53]
BALB/c (infar1)	More susceptible to viral Infections. Affects NK	BALB/c	↔	↔	[61]
C57BL/6 (INFαβR)	More susceptible to viral Infections. Affects NK	129 Sv/Ev	ND	↓	[62]
C57BL/6 (TCRδ)	Absence of Tγδ cells	C57BL/6	↑	↔	[60]
C57BL/6 (GM-CSF)	Higher lung infection Defective alveolar macrophages	C57BL/6	↔	↔	[60]
C57BL/6 (IL-17Rα)	Defective in PMN recruitment and PMN activity	C57BL/6	↔	ND	[60]
C57BL/6 (IL-1β)	Low proinflammatory response	C57BL/6	↔	↔	[50]
C57BL/6 (IL-18)	Early activation of NK and Th1 cells	C57BL/6	↔	↔	[50]
C57BL/6 (IL-1βx IL-18)	Low proinflammatory response and recruitment of NK and Th1 cells	C57BL/6	↔	↔	[50]
C57BL/10 (TNF-α)	Low proinflammatory response	C57BL/10	↑	ND	[63]

Brucella susceptibility order: CBA/H>CBA/NJ=CD-1=BALB/c=C3H/HeN=C3H/HeJ>C57BL/10=C57BL/6≥B10Br.
^a (↑) Significantly higher numbers of CFU in spleen than in controls; (↓) significantly lower numbers of CFU in spleen than in controls; (↔) no significant number of CFU in spleen in relation to the controls; ND, not done.

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ISSN: 1297-9716

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