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Figure 7 | Veterinary Research

Figure 7

From: Stimulation with a class A CpG oligonucleotide enhances resistance to infection with feline viruses from five different families

Figure 7

Subcutaneous injection of ODN 2216 induces a systemic antiviral state in vivo. (A) The cats received an injection of either 200 μg/kg ODN 2216 (cats 1 and 2) or endotoxin-free PBS (cats 3 and 4). Mx mRNA expression was measured by qPCR in whole blood. Depicted values represent the ratio of mRNA levels for a given cat (c05-c08) at the indicated time point to mRNA levels for the same cat at time point 0 h. (B) fcwf-4 cells were incubated for 24 h in duplicates with plasma collected from the cats 1 to 4 at the indicated time points post injection, and inoculated with the FCV. Indicated are viral inhibition factors calculated as described in the material and methods section. (C) Mx mRNA expression factors measured in the blood of all four cats at time points 8 h-192 h were correlated with the inhibition of FCV induced in vitro by the corresponding plasma samples.

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