Tissue* | 3 dpi | 5 dpi | 8 dpi | 15 dpi | Predominant cell types | Associated lesion |
---|---|---|---|---|---|---|
Gizzard | – | ++ | – | – | Epithelial cells of the ventricular glands | Severe multifocal necrosis, mild lymphoplasmacytic infiltrate |
Cecal tonsil | – | + | – | – | Epithelial cells of the glands, cells of the muscularis externa | Focal necrosis, mild lymphoplasmacytic infiltrate |
Pancreas | – | ++ | +++ | – | Acinar cells, endothelial cells | Severe multifocal to coalescent lytic necrosis, lymphoplasmacytic infiltrate, edema |
Nasal turbinates | + | – | – | – | Respiratory epithelial cells | Lymphoplasmacytic infiltrate in lamina propria |
Trachea | – | + | – | – | Goblet cells | NSL |
Heart | – | ++ | – | – | Myocardiocytes, endothelial cells | Severe multifocal necrosis, mild lymphoplasmacytic infiltrate |
Spleen | – | + | + | – | Endothelial cells, macrophages | NSL |
Brain | – | +++ | ++ | – | Neurons, Purkinje cells, ependymal cells, glial cells, endothelial cells | Malacia in cortex, necrosis of ependymal cells of ventricles and epithelial cells of choroid plexus, chromatolysis of Purkinje cells, lymphoplasmacytic infiltrate |
Spinal cord | – | +++ | – | – | - | Malacia in grey matter, necrosis of the ependyma and neuropil |