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Table 3 Average distribution of AIV-NP antigen in positive tissues from quail intranasally challenged with H7N1/HP

From: Pathobiology and transmission of highly and low pathogenic avian influenza viruses in European quail (Coturnix c. coturnix)

Tissue*

3 dpi

5 dpi

8 dpi

15 dpi

Predominant cell types

Associated lesion

Gizzard

++

Epithelial cells of the ventricular glands

Severe multifocal necrosis, mild lymphoplasmacytic infiltrate

Cecal tonsil

+

Epithelial cells of the glands, cells of the muscularis externa

Focal necrosis, mild lymphoplasmacytic infiltrate

Pancreas

++

+++

Acinar cells, endothelial cells

Severe multifocal to coalescent lytic necrosis, lymphoplasmacytic infiltrate, edema

Nasal turbinates

+

Respiratory epithelial cells

Lymphoplasmacytic infiltrate in lamina propria

Trachea

+

Goblet cells

NSL

Heart

++

Myocardiocytes, endothelial cells

Severe multifocal necrosis, mild lymphoplasmacytic infiltrate

Spleen

+

+

Endothelial cells, macrophages

NSL

Brain

+++

++

Neurons, Purkinje cells, ependymal cells, glial cells, endothelial cells

Malacia in cortex, necrosis of ependymal cells of ventricles and epithelial cells of choroid plexus, chromatolysis of Purkinje cells, lymphoplasmacytic infiltrate

Spinal cord

+++

-

Malacia in grey matter, necrosis of the ependyma and neuropil

  1. *Tissues not present appeared overtly normal on histopathological analysis and did not show positive IHC staining.
  2. – = no positive cells; + = single positive cells; ++ = scattered groups of positive cells; +++ = widespread positivity.
  3. dpi, days post-inoculation; NSL, no significant lesions.