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Figure 3 | Veterinary Research

Figure 3

From: Impact of genotype 1 and 2 of porcine reproductive and respiratory syndrome viruses on interferon-α responses by plasmacytoid dendritic cells

Figure 3

PRRSV sensing by pDC does not require live virus and is mediated via TLR7. (A) IFN-α induced by type 1 and 2 PRRSV (MOI of 1 TCID50/cell) in enriched pDC does not require live virus and is potentiated synergistically by IFN-γ. (B) Production of IFN-α by enriched pDC exposed to PRRSV (MOI of 2.5 TCID50/cell) is inhibited by IRS661, a TLR7 antagonist. IFN-α was determined by ELISA in supernatants harvested after 20 h. Bars indicate biological triplicates ± 1 standard deviation in one representative experiment out of two.

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Veterinary Research

ISSN: 1297-9716