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Table 4 Genes most significantly differentially expressed by bMEC stimulated by LPS for 3 and 6 h compared to unstimulated cells, ordered by functional classes

From: Differential response of bovine mammary epithelial cells to Staphylococcus aureus or Escherichia coli agonists of the innate immune system

Gene symbol

Gene description

Fold change

3 h

6 h

Transcription and activation pathways

  

  NFKBIA

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

3.60

4.53

  BIRC3

Baculoviral IAP repeat-containing protein 3

3.10

3.19

  ZNFX1

NFX1-type zinc finger-containing protein 1

 

3.11

  ZNHIT3

Zinc finger HIT domain-containing protein 3

2.48

3.08

  IKBKAP

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

2.52

2.33

  TRIM21

Tripartite motif-containing protein 21

1.61

2.26

  CEBPD

CCAAT/enhancer binding protein (C/EBP), delta

2.02

1.60

  NFKB2

Nuclear factor of κ light polypeptide gene enhancer in B-cells 2

1.78

1.94

  JAK2

Janus kinase 2

1.90

1.85

  DUSP1

Dual specificity phosphatase 1

 

1.85

  FOS

V-fos

 

-2.01

  PLK2

Serum-inducible kinase, transcript variant 1,PLK2

-1.50

 

Cytokines and chemokines, growth factors

  

  CCL5

RANTES

7.10

20.52

  CCL20

Chemokine (C-C motif) ligand 20

19.42

19.37

  CXCL8

Chemokine (C-X-C motif) ligand 8, Interleukin-8

8.53

13.96

  CXCL5

Chemokine (C-X-C motif) ligand

4.75

7.96

  CCL2

Chemokine (C-C motif) ligand 2

 

6.38

  CXCL2

Chemokine (C-X-C motif) ligand 2

 

5.06

  CXCL1

Chemokine (C-X-C motif) ligand 1

4.93

 

  IL6

Interleukin 6

6.64

4.85

  CXCL3

Chemokine (C-X-C motif) ligand 3

3.15

3.60

  IL1B

Interleukin 1, beta

5.01

3.32

  IFNB

Interferon beta precursor

4.89

3.25

  TNFSF13B

Tumor necrosis factor (ligand) superfamily, member 13 (BAFF)

2.96

 

  IL2

Interleukin 2

4.30

2.86

  CCL16

Chemokine (C-C motif) ligand 16

2.60

2.77

  CSF2

Colony stimulating factor 2 (granulocyte-macrophage)

1.69

2.10

  IL23A

Interleukin 23, alpha subunit p19

 

2.06

  CTGF

Connective tissue growth factor

-1.92

 

  TGFB2

Transforming growth factor beta-2 precursor

 

-1.46

Type I IFN-related genes

  

  IFIT3

Interferon-induced protein with tetratricopeptide repeats 3

3.02

7.92

  MX1

Myxovirus (influenza virus) resistance 1

1.84

2.93

  IFIH1

Interferon induced with helicase C domain 1

2.65

4.10

  ISG15

ubiquitin-like modifier

2.46

3.69

  GBP1

Interferon-induced guanylate-binding protein 1

2.17

3.56

  TNFSF10

Tumor necrosis factor ligand superfamily member 10 (TRAIL)

2.02

3.13

  IFI44

Similar to Interferon-induced protein 44

 

3.23

  OAS1

2′-5′-oligoadenylate synthetase 1

1.61

3.15

  IFI27L1

Interferon alpha-inducible protein 27-like protein 1

 

2.88

  IRF7

Interferon regulatory factor 7

1.45

2.75

  TRIM21

Tripartite motif-containing protein 21

1.61

2.26

  GVIN1

GTPase, very large interferon inducible 1

 

2.21

  STAT2

Signal transducer and activator of transcription 2

 

2.01

  STAT1

Signal transducer and activator of transcription 1

 

1.96

  IRF2

Interferon regulatory factor 2

 

1.84

Immune defense response

  

  NOS2A

Nitric oxide synthase 2A (inducible)

5.57

7.45

  S100A8

Calcium-binding protein A8, calgranulin A

2.87

7.00

  CFB

Complement factor B

3.39

5.02

  S100A9

Calcium-binding protein A9, calgranulin B

2.40

4.59

  CD83

Cell surface protein HB15

5.50

3.40

  C2

C2 Complement component 2

1.79

2.64

  ICAM1

Intercellular adhesion molecule 1

2.50

 

  LTF

Lactotransferrin

 

2.47

  PLAT

Plasminogen activator, tissue type

1.93

2.11

  PLAUR

Urokinase plasminogen activator surface receptor

2.11

1.96

  CAMP

Cathelicidin antimicrobial peptide

 

1.89

  TLR4

Toll-like receptor 4

1.62

1.81

  MMP9

Matrix metallopeptidase 9

 

1.77

  CD74

Major histocompatibility complex, class II invariant chain

 

1.75

  BNBD10

Beta-defensin 10

1.59

1.67

Stress response

  

  SOD2

Superoxide dismutase 2

3.19

5.05

  SGK1

Serum/glucocorticoid regulated kinase 1

1.81

4.79

  PARP14

Poly (ADP-ribose) polymerase family, member 14

 

2.95

Cell growth and cycle, apoptosis

  

  IGFBP3

Insulin-like growth factor binding protein-3

2.38

5.27

  EIF4E

Translation initiation factor 4E

2.32

5.20

  CASP4

Caspase-4 Precursor

1.60

3.04

  CASP8

Caspase-8 precursor

1.58

2.29

  IER3

Immediate early response 3

2.09

 

  TNFRSF6

TNF receptor superfamily, member 6 (FAS)

1.82

1.86

  CDK2AP1

Cyclin-dependent kinase 2 associated protein 1

 

-1.66

  EI24

Etoposide-induced protein 2.4 homolog

 

-1.65