Table 7 Functional pathways of genes most affected by SaS stimulation, determined by using the Genomatix Pathway System (GePS)

Signal transduction pathways (canonical)

AP-1 transcription factor network

5.05 × 10^-7

6/69

Signal transduction pathways (Genomatix)

Interleukin 17A

8.75 × 10^-7

7/137

Protein kinase B

1.59 × 10^-6

9/297

Baculoviral IAP repeat containing protein,

1.94 × 10^-6

9/304

apoptosis inhibitor

FBJ murine osteosarcoma viral oncogene

6.49 × 10^-6

4/32

homolog B

Cyclin D1

7.69 × 10^-6

10/461

Chemokine (CC motif) ligand 2

8.40 × 10^-6

8/272

Molecular functions (GO)

Too few genes, p value > 10^-5

Biological processes (GO)

Too few genes, p value > 10^-5

SaS vs Ref 6 h (213 genes taken into account)

Signal transduction pathways (canonical)

Too few genes, p value > 10^-5

Signal transduction pathways (Genomatix)

Minichromosome maintenance complex

6.13 × 10^-7

7/42

Cyclin B1

9.29 × 10^-7

10/112

Cyclin D1

2.34 × 10^-6

19/461

DNA repair

4.43 × 10^-6

23/725

Cyclin A2

4.37 × 10^-6

11/167

Checkpoint

2.51 × 10^-5

16/402

Interleukin 17A

4.07 × 10^-5

10/137

Nuclear receptor subfamily 3, group C

4.08 × 10^-5

10/171

Cell cycle

4.94 × 10^-5

32/1309

Aryl hydrocarbon receptor

9.93 × 10^-5

10/190

Molecular functions (GO)

Protein binding

2.95 × 10^-5

100/8067

Protein heterodimerizaton activity

1.23 × 10^-4

9/202

Oxidoreductase activity

2.39 × 10^-4

17/685

Biological processes (GO)

Symbiosis, encompassing mutualism

2.15 × 10^-5

6/58

Viral reproduction

3.84 × 10^-5

7/94

Cell death

1.05 × 10^-4

27/1275

Death

1.10 × 10^-4

27/1279

Response to organic substance

1.24 × 10^-4

21/874

Oxidation reduction

1.98 × 10^-4

17/645