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Figure 4 | Veterinary Research

Figure 4

From: Antigen dose and humoral immune response correspond with protection for inactivated infectious pancreatic necrosis virus vaccines in Atlantic salmon (Salmo salar L)

Figure 4

Pathological changes during the acute stage of infection. a) Gross picture showing hemorrhages (arrow) in the area of the exocrine pancreas of Atlantic salmon smolt. b) Destruction and necrosis of pancreatic acinar cells due to IPNV infection (arrow) with pyknotic nuclei (*). c) Different stages of cellular degradation and apoptosis (long horizonal arrow) in the liver (vertical arrow). d) Extensive distribution of virus in the liver (red coloration). e) Virus in interstitial spaces and leukocytes of the excretory kidney. Melanomacrophages (M) appear as dark spots. f) Virus in the white (W) and red (R) pulps of the spleen.

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