Figure 5

Model for the coordinated response to dsRNA after vaccination with the inactivated vaccine PregSure® against ssRNA BVD virus. Coloured boxes indicate differentially expressed genes or significantly affected pathways when comparing gene expression before and after vaccination. Red boxes indicate intracellular sensors of dsRNA; blue boxes indicate other genes or pathways. Red arrow indicates transport of dsRNA into the cell, the blue dotted lines indicate activation of dsRNA sensors by dsRNA, and the blue solid lines indicate other regulatory or activating effects.