Evaluation of a 3A-truncated foot-and-mouth disease virus in pigs for its potential as a marker vaccine

Table 3 Responses of pigs to vaccination with r-HN or r-HN/3A _93–143 chemically inactivated vaccines and r-HN challenge

Vaccine^a	Pig	Protection^b	LPBE-antibody^c(dpi)	3ABC antibody^d(dpi)
r-HN/3A_93–143	3501	yes	1:180	–
	3502	yes	1:512	–
	3503	yes	1:64	–
	3504	yes	1:128	–
r-HN	3505	yes	1:90	–
	3505	yes	1:256	–
	3507	yes	1:256	–
	3508	yes	1:32	–
Negative controls	3509	no	1:4	+
Negative controls	3510	no	1:4	+

^aBinary ethyleimine-inactivated antigen vaccine, 2 μg/2 mL in one dose.
^bPigs were challenged by intramuscular inoculation of 1000 ID₅₀ of r-HN.
^cLPBE-antibody, liquid-phase blocking ELISA antibody. Dpi here indicates four-weeks after vaccination that LPBE-antibodies were detected.
^d3ABC antibody, the antibody to the nonstructural protein 3ABC of FMDV. Dpi here indicates three-weeks after challenge that 3ABC antibodies were detected. +, positive, −, negative.

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