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Figure 7 | Veterinary Research

Figure 7

From: Duck MDA5 functions in innate immunity against H5N1 highly pathogenic avian influenza virus infections

Figure 7

H5N1 HPAIV NS1 interferes with chIFN-β and chIRF-7 induction. The DEF cells were cotransfected with (A) pGL3-chIFNβ-Luc or (B) pGL3-chIRF-7-Luc and the pTK-RL plasmid and with pCAGGS-MDA5-CARD and with pCAGGS-DK212-NS1 or with the empty plasmid. Dual-luciferase assays were performed after 36 h. The DEF cells were cotransfected with (C) pGL3-chIFNβ-Luc or (D) pGL3-chIRF-7-Luc and the pTK-RL plasmid. After 12 h, the cells were infected with DK212 or rDK212-ΔNS1 at different doses. Dual-luciferase assays were performed after 24 h.

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