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Table 4 Efficacy of B. ovis LPS mutants in BALB/c mice against a virulent B. ovis infection

From: Mutants in the lipopolysaccharide of Brucella ovis are attenuated and protect against B. ovis infection in mice

Vaccine (dose/route)

Log10CFU in spleen (mean ± SD)

No. of non-infected/ total mice studied

BoΔwadB (108/IP)

1.08 ± 1.22a,c

7/10a,c

BoΔwadC (108/IP)

2.18 ± 1.59a

5/10b

B. melitensis Rev 1 (105/SC)

2.75 ± 1.26b

2/10

PBS (unvaccinated control)

6.24 ± 0.48c

0/10

  1. ap < 0.005 and , bp < 0.05 vs. unvaccinated control; cp < 0.05 vs. Rev 1 control.