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Table 3 H5N1 and H5N9 HI titers in breeders and their progeny

From: Immunogenicity and efficacy of fowlpox-vectored and inactivated avian influenza vaccines alone or in a prime-boost schedule in chickens with maternal antibodies

Study

Type of breeders (age at egg harvest)

HI titers*in breeders

HI titers in progeny

Age at blood sampling

H5N1

H5N9

H5N1

H5N9

1

H5N9 + FP (42 weeks)

36 weeks

4.0 ± 1.8

7.5 ± 2.2

2.0 ± 2.2

3.5 ± 3.0

44 weeks

2.9 ± 2.1

7.5 ± 2.5

2

H5N9 + FP (62 weeks)

60 weeks

3.5 ± 1.9

6.5 ± 2.7

1.0 ± 1.7

3.1 ± 2.7

68 weeks

3.0 ± 1.9

6.6 ± 2.1

3

H5N9 (24-25 weeks)

20 weeks

4.9 ± 2.0

7.1 ± 1.7

3.0 ± 1.9

4.3 ± 2.0

28 weeks

4.3 ± 2.5

5.9 ± 2.0

H5(N8) + H5N9 + FP (24-25 weeks)

20 weeks

ND**

7.0 ± 1.6

1.8 ± 1.1

3.0 ± 1.9

28 weeks

ND

5.3 ± 1.9

4

H5N9 (58 weeks)

52 weeks

3.9 ± 2.7

5.0 ± 2.1

ND

3.4 ± 0.9

60 weeks

4.6 ± 2.2

5.8 ± 2.3

  1. Breeders hens were vaccinated with inH5N9 and fowlpox (H5N9 + FP), inH5N9 only (H5N9) or with vFP89, inH5N9 and fowlpox (H5(N8) + H5N9 + FP). Their serums were taken at two time points flanking the time of harvest of their eggs. Serums of their progeny were sampled at 1 day-of-age. NIBRG14 and NIRG23 H5N1 antigens were used in studies 1 & 2 and studies 3 & 4, respectively.
  2. *mean HI titer ± standard deviation in log2.
  3. **ND means not done.