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Table 1 Principal results obtained with BoHV-1 and BoHV-5 gD vaccines

From: Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology

Vaccine

Virus

Expression

Adjuvant

Route

Immune Resp.

Protection

Ref.

  

system

  

Humoral

Cellular

  

Subunit

BoHV-1

Native gD

Avridine

i.m.

++++

n/a

xxxx

[60],[61]

 

BoHV-1

E. coli

Avridine

i.m.

++

n/a

xx

[62]

 

BoHV-1

P. pastoris

Oil

i.m.

++++

++

n/a

[63],[64]

 

BoHV-5

P. pastoris

Oil

i.m.

++++

++

n/a

[25]

 

BoHV-1

MDBK

Oil

i.m.

++++

++

xx

[69],[70]

 

BoHV-1

MDBK

CpG; Alum

i.m.

++++

++++

xxxx

[71]

 

BoHV-1

MDBK

CpG; Oil

s.c.

++++

++++

xxxx

[72]

 

BoHV-1

Plant cellsa

Oil

i.p., s.c, i.m.

n/a

n/a

xx

[66]

DNA

BoHV-1

pRSV

n/a

i.m.

++++

n/a

xx

[79]

 

BoHV-1

HCMV

n/a

i.d.

++++

++++

xxxx

[80]

 

BoHV-1

HCMV

n/a

i.m.

++++

++++

xxxx

[82]

 

BoHV-1

HCMV

CpG

i.d.

++

++++

xx

[83]

Vectored

BoHV-1

BAV-3

n/a

i.n

++

++++

xx

[87],[88]

 

BoHV-1

HAd5

n/a

i.n

++

n/a

xxxx

[89],[90]

  1. a = achieved with a Tobacco Mosaic Virus (TMV)-based vector.
  2. ++ = Weak neutralizing antibodies or cell-mediate response.
  3. ++++ = Strong neutralizing antibodies or cell-mediate response.
  4. n/a = Data not available.
  5. xx = Partial protection.
  6. xxxx = Total protection.