Bovine Neonatal Pancytopenia is a heritable trait of the dam rather than the calf and correlates with the magnitude of vaccine induced maternal alloantibodies not the MHC haplotype

Table 2 Comparison of MHC class I haplotype frequencies in Pregsure© BVD vaccinated non-BNP and BNP dams

MHC class I Haplotype^a	Non-BNP dams (n = 27)	BNP dams (n = 22)	P-value^b	FDR-derived significance thresholds^c
A19 variants	5	11	0.053	0.003
H2	4	0	0.125	0.006
A13	2	6	0.135	0.009
UU6	0	2	0.199	0.012
UU5	0	1	0.449	0.015
A20v3 (UU)	5	2	0.454	0.018
UU1	2	0	0.500	0.021
A11	3	1	0.625	0.024
A10	4	2	0.688	0.026
H5v2 (UU)	4	2	0.688	0.029
A14	9	6	0.782	0.032
A15v1	9	8	1.000	0.035
A12vUU	3	2	1.000	0.038
UU3	1	0	1.000	0.041
A18v2	1	0	1.000	0.044
UU4	1	0	1.000	0.047
UU7	1	1	1.000	0.050

^aBovine MHC class I haplotypes are based on Codner et al. [17] and results from this study (detailed in Additional file 2).
^bOrdered P-values from Fisher’s exact test.
^cTo adjust for multiple comparisons the False Discovery Rate (FDR) was controlled at 5% using the principle from Benjamini and Hochberg [19]. The largest P-value lower than its FDR-derived significance threshold and all P-values smaller are significant.

ISSN: 1297-9716