Skip to main content

Table 1 Ovine TMEM154 haplotypes and their associations with infection susceptibility and SRLV subgroups

From: Genetic subgroup of small ruminant lentiviruses that infects sheep homozygous for TMEM154 frameshift deletion mutation A4Δ53

Haplotype

Amino acid at position indicated

Allelic effect b

SRLV association

4 a

13

14

25

31

33

35

44

70

74

82

102

1

R

A

L

T

E

D

K

T

N

I

E

I

Less-susceptible

Subgroup 1

2

R

A

L

T

E

D

E

T

I

I

E

I

Highly-susceptible

Subgroup 2

3

R

A

L

T

E

D

E

T

N

I

E

I

Highly-susceptible

Subgroup 2

4

A

Pc

Fc

Pc

Rc

Tc

Nc

Wc

NAd

NA

NA

NA

Unknown

Unknown, can be infected by Subgroup 4 (this study)

6

R

A

L

T

E

D

E

T

N

I

Y

NA

Unknown

Unknown

9

R

A

L

T

E

N

E

T

N

I

E

I

Unknown

Unknown

10

R

A

H

T

E

D

K

T

N

I

E

I

Unknown

Unknown

11

R

A

L

I

E

D

E

T

N

I

E

I

Unknown

Unknown

12 e

R

A

L

T

E

D

E

T

N

F

E

I

Unknown

Unknown

13

R

V

L

T

E

N

E

T

N

I

E

I

Unknown

Unknown

14

R

A

L

T

E

D

E

T

N

I

E

T

Unknown

Unknown

15 e

R

A

L

T

Q

D

E

T

N

F

E

I

Unknown

Unknown

  1. aNumbers refer to amino acid positions in [GenBank:HM355886].
  2. bDoes not account for SRLV subgroups.
  3. cResult of frameshift mutation at amino acid position 4.
  4. dNot applicable due to preceding premature stop codon.
  5. eHaplotype observed in wild sheep.