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Figure 3 | Veterinary Research

Figure 3

From: TGF-β superfamily members from the helminth Fasciola hepatica show intrinsic effects on viability and development

Figure 3

Amino acid sequence and predicted 3D structure of FhTLM. (A) Amino acid sequence showing corresponding nucleotide sequence along the putative cleavage site is shaded in light blue. The active TGF-β domain is shown blue shaded and sequences in pink background indicate the conserved cysteine residues in the active domain. (B) 3D structure of predicted FhTLM from Phyre2 by homology search modelling based on template 3rjrD (Sus scrofa TGF-β1). Full FhTLM protein; Full 3rjrD protein; FhTLM active domain; active domain of 3rjrD. On the models blue indicates the N-terminus and red indicates the C-terminus. The secondary structure components of FhTLM are composed of 13 α-helices and 16 β-sheets and 3rjrD are composed of 7 α-helices and 19 β-sheets.

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