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Table 2 Up-regulated canonical pathways in PMEC at 3 hpc

From: Gene expression profiling of porcine mammary epithelial cells after challenge with Escherichia coli and Staphylococcus aureus in vitro

E. coli- challenged vs. unchallenged control cells

 

Canonical pathway (Genes involved in pathway)

p -value

Granulocyte Adhesion and Diapedesis(CXCL3,IL1A,VCAM1,ICAM1,CCL2,CLDN1,CXCL1,CXCL2,IL1RAP,CXCL6,ITGB3)

8.52E-11

Interferon Signaling(IFIT3,IFIT1,JAK2,IFNAR2,IFNAR1,IRF1)

4.11E-09

Agranulocyte Adhesion and Diapedesis(CXCL3,IL1A,VCAM1,ICAM1,CCL2,CLDN1,CXCL1,CXCL2,CXCL6)

4.92E-08

Hepatic Fibrosis/Hepatic Stellate Cell Activation(CXCL3,IL1A,VCAM1,ICAM1,CCL2,IFNAR2,IL1RAP,IFNAR1)

8.20E-08

Role of IL-17A in arthritis(CXCL3,NFKBIA,CCL2,CXCL1,CXCL6)

2.43E-06

S. aureus- challenged vs. unchallenged control cells

 

Canonical pathway (Genes involved in pathway)

p -value

Bupropion Degradation

3.44E-06

Acetone Degradation I (to Methylglyoxal)

3.86E-06

Estrogen Biosynthesis

1.11E-05

Nicotine Degradation III

2.87E-05

Melatonin Degradation I(CYP1A1,CYP3A4,CYP1B1 are involved in all five canonical pathways)

3.39E-05

  1. Top five categories of up-regulated canonical pathways in PMEC at 3 hpc with E. coli and S. aureus, respectively, compared with unchallenged control cells with their respective p-value and genes involved in each pathway obtained from IPA software.