Table 5 Down-regulated canonical pathways in PMEC at 24 hpc
E. coli- challenged vs. unchallenged control cells | |
|---|---|
Canonical pathway (Genes involved in pathway) | p -value |
Estrogen-mediated S-phase Entry(CCNA2,E2F4,CCNE1,TFDP1,E2F1,CDK2) | 1.84E-05 |
Protein Ubiquitination Pathway(USP28,PSMB9,DNAJC9,MED20,HSPA1A/HSPA1B,HSPH1,UBE2N,UBE2R2,HSPA6,CDC23,UBE2S,DNAJA1,HSPA5,TAP1,DNAJC11,USP31,USP3,PSMD12,USP46,USP34,BIRC) | 5.29E-04 |
Adenine and Adenosine Salvage I(PNP) | 5.89E-04 |
Phosphatidylglycerol Biosynthesis II (Non-plastidic)(GPAM,ABHD5,PTPMT1,MBOAT2) | 6.36E-04 |
Cell Cycle: G1/S Checkpoint Regulation(E2F4,CCNE1,CCND2,TFDP1,E2F1,GNL3,CDK2) | 7.40E-04 |
S. aureus- challenged vs. unchallenged control cells | |
Canonical pathway (Genes involved in pathway) | p -value |
Phosphatidylglycerol Biosynthesis II (Non-plastidic)(GPAM,ABHD5,PTPMT1,MBOAT2) | 4.27E-04 |
Protein Ubiquitination Pathway(DNAJC9,HSPA1A/HSPA1B,HSPH1,UBE2N,UBE2R2,HSPA6,DNAJC25,CDC23,UBE2S,DNAJA1,HSPA5,DNAJC11,PSMD12,USP46,USP34) | 5.14E-04 |
Aldosterone Signaling in Epithelial Cells(ICMT,DNAJC9,HSPA1A/HSPA1B,HSPH1,HSPA6,DNAJC25,DNAJA1,HSPA5,PRKCZ,DNAJC11,PIK3R3,SCNN1G,PRKD1) | 5.21E-04 |
Estrogen-mediated S-phase Entry(E2F4,CCNE1,TFDP1,E2F1) | 1.69E-03 |
Vitamin-C Transport(SLC2A1,TXN,TXNRD1) | 3.15E-03 |