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Table 2 Results of the pathogenicity and by contact transmission experiment

From: Susceptibility to and transmission of H5N1 and H7N1 highly pathogenic avian influenza viruses in bank voles (Myodes glareolus)

Virus

Sample

Day pi/pc

Infected

Sentinels

RRT-PCR

Ct ± SD

VI

RRT-PCR

Ct

VI

Os/H7N1

Lungs

3

+2/2

26.22 ± 1.1

+2/2

-

-

nt

4

+2/2

22.33 ± 0.08

+2/2

+1/2

28.24

+1/1

Nasal wash

3

+1/2

32.13

-

-

-

nt

4

+1/2

30.57

-

+1/2

35

-

Brain

3

+1/2

30.01

-

-

-

nt

4

-

-

nt

-

-

nt

Spleen

3

+2/2

28 ± 3.5

+1/2

-

-

nt

4

-

-

nt

-

-

nt

Kidney

3

+1/2

29.6

-

-

-

nt

Tk/H5N1

Lungs

2a

+1/1

20.22

+1/1

nt

nt

nt

3

+2/2

22.19 ± 2

+2/2

-

-

nt

4

+2/2

27.3 ± 3.4

+2/2

+1/2

24.03

+1/1

Nasal wash

2a

+1/1

26.95

-

nt

nt

nt

3

+2/2

29 ± 2.1

+2/2

-

-

nt

4

+2/2

34.7 ± 0.1

-

-

-

nt

Brain

2a

-

-

nt

nt

nt

nt

3

-

-

nt

-

-

nt

4

+1/2

33.48

-

-

-

nt

Spleen

2a

+1/1

33.12

-

nt

nt

nt

3

-

-

nt

-

-

nt

4

-

-

nt

-

-

nt

  1. pi: post-infection; pc: post-contact; Ct: quantification cycle; SD: standard deviation; VI: virus isolation; adead vole with clinical signs on day 2 pi; −: all samples tested negative; nt: not tested.
  2. RRT-PCR (mean of Ct values ± SD) and virus isolation results of the different organs and nasal washes collected from infected voles and in contact sentinels on days 3 and 4 pi/pc.