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Figure 4 | Veterinary Research

Figure 4

From: Comparison of the pathogenesis of the highly passaged MCMV Smith strain with that of the low passaged MCMV HaNa1 isolate in BALB/c mice upon oronasal inoculation

Figure 4

Identification of MCMV-infected cells in the nasal mucosa, lungs and submandibular glands. Nuclei were counterstained with Hoechst (Blue). Co-localization appears yellow in the merged images. The zoomed images show the boxed region of merged layers. Cryosections of the nasal mucosa were double-stained with antibodies against MCMV antigens (by pα-MCMV Abs) and cell markers: OMP (olfactory neuron marker), cytokeratin-18 (epithelial marker), CD68 (tissue macrophages) and CD11c (dendritic cells). Olfactory neurons and sustentacular cells of the olfactory epithelium (olfactory EP) in the nasal mucosa were susceptible for MCMV. Infected cells of NALT in the nasal mucosa were CD68+/CD11c+. Epithelial cells (cytokeratin-18+) of submandibular glands were susceptible for MCMV. Epithelial cells (cytokeratin-18+) and macrophages (F4/80+) were positive for MCMV in lungs.

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