Figure 2

Physiological and alveolar capillary evaluation. WT mice were infected per os with 1.10⁷ PFU of MNV or PBS (n = 10/group). A week later, mice were infected with intranasal instillation of 2.10⁶ CFU of P. aeruginosa or PBS. Changes in body weight (A) and score diseases (B) were evaluated and mice were sacrificed at 24 h post-infection. Lung injury was assessed by alveolar capillary barrier permeability (C) and cells from Bronchoalveolar Lavage were counted (BAL) (D–F). *, P < 0.05; **, P < 0.01; ***, P < 0.001.