Biological functions of Lpro | Auto cleavage | Cleavage activities | Deubiquitination activity | Unknown | ||
---|---|---|---|---|---|---|
Target proteins | Viral polyprotein [4] | Daxx [54] | RIG-I,TBK1,TRAF3 and TRAF6 [22] | |||
Recognition site/region | KVQRKLK201*GAGQSS | eIF4GI:PSFANLG674 *RTTLST; eIF4GII:VPLLNVG700 *SRRSQP | PABP: putative motif RRSL; Gemin5:IKKRKAR846*SLLPLS(RKAR motif); others: unknown | Daxx:VLARRLR360*ENRSLA (RRLR motif) | The polyubiquitination chain of ubiquitinated signaling molecules | Unknown |
The effects induced by Lpro | Directing the release of Lpro from the nascent polyprotein | Shutting off cellular translation | Control of cellular translation | Regulation of apoptosis and innate immune antiviral responses | Impairing innate immune signaling pathways | Restricting antiviral activities of IFN-α/β and IFN-λ1 |