Exp I | Exp II | |
---|---|---|
Gender | Males | Females |
Groups | 4, 6 mice per group | 3, 16 mice per group |
Mating | No | Yes |
Challenge | Nc-Spain 7 (105) | Nc-Spain 7 (105), 7 days post mating |
Treatment | ARI, ARO, MEF, placebo; days 2–7 pi | BPQ, placebo; days 2–7 pi |
Euthanasia | 21 days pi | non-pregnant: 21 days pi dams: 30 days after birth, i.e., 44 days pi |
Parameters | N. caninum load in brains and lungs, serum titer | Number of pups, N. caninum brain load, serum titer |