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Figure 2 | Veterinary Research

Figure 2

From: L-BSE experimentally transmitted to sheep presents as a unique disease phenotype

Figure 2

Immunohistochemistry representative of ovine L-BSE. All figures illustrate labelling with mAb 2G11, except B. Neuronal and particulate labelling is present in the DNV with mAb 2G11 (A), but absent with mAb P4 (B) (case 455/11). Particulate labelling and small aggregates are abundant in many areas, such as the thalamic nuclei (C) (case 1591/10). Perineuronal labelling in the putamen is a consistent and striking feature of ovine L-BSE (D) (case 1591/10), as is intracellular labelling of oligodendrocytes, seen here in the spinocerebellar tract (rostral medulla) (E) (case 58/11). Intraneuronal labelling is also present in the DRG (F) (case 4/12). Heavy labelling in muscle spindles is also visible (G) (case 267/11) and also in occasional myocytes (H) (case 98/11). Labelling was also present in the LRS (I) and ENS (J) of one VRQ/VRQ recipient (case 48/13).

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