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Figure 1 | Veterinary Research

Figure 1

From: Recent knowledge on hepatitis E virus in Suidae reservoirs and transmission routes to human

Figure 1

Phylogenetic tree of HEV sequences within the species Orthohepevirus A. Forty-one complete genomes or complete coding reference sequences available in the GenBank database and representative of each genotype sequences, as published by Smith et al. [44], were aligned using Muscle (MEGA6 [130]). The tree was obtained by applying the Neighbor-Joining method to a matrix of pairwise distances estimated using the Maximum Composite Likelihood (MCL) approach (MEGA6 [130]). The tree is drawn to scale, with branch lengths proportional to the number of substitutions per site. HEV genotypes are indicated for each group: HEV-1 to HEV-7 (HEV-3ra: rabbit subtype of HEV-3). Silhouettes of human or animal species indicate natural hosts. Human HEV are in green and zoonotic HEV in purple. HEV-5 and HEV-6 are in striped purple since their zoonotic potential remains to be proven.

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