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Table 3 The differential expression genes in the Δ27735 mutant compared to the WT strain

From: The putative amino acid ABC transporter substrate-binding protein AapJ2 is necessary for Brucella virulence at the early stage of infection in a mouse model

Gene locus

Gene products

Regulation

2−∆∆Ct ± SD

Replication, recombination and repair

 bab_RS18500

Transposase

Up

1.13 ± 0.11

 bab_RS20725

Transposase, is4 family

Down

0.81 ± 0.05

Amino acid transport and metabolism

 bab_RS30275

Extracellular ligand-binding receptor

Up

1.66 ± 0.44*

Energy production and conversion

 bab_RS30280

NADPH quinone oxidoreductase

Up

1.77 ± 0.23*

Post-translational modification, protein turnover, and chaperones

 bab_RS26600

Heat shock protein

Up

1.22 ± 0.13

Cell motility

 bab_RS26930

Flagellar motor switch protein

Up

1.69 ± 0.17*

 bab_RS31530

Flagellar biosynthesis protein

Up

1.53 ± 0.25*

 bab_RS27100

Flagellar L-ring protein

Down

0.82 ± 0.16

Transcription

 bab_RS31650

AraC family transcriptional regulator

Down

0.73 ± 0.12

 bab_RS29200

IclR family transcriptional regulator

Down

0.69 ± 0.07

Defense mechanisms

 bab_RS28255

Type I restriction DNA specific modify protein

Down

0.73 ± 0.07

Function unknown

 bab_RS18900

Hypothetical protein

Up

1.84 ± 0.56*

 bab_RS30140

LmbE family

Up

1.71 ± 0.38*

 bab_RS18875

Putative Gene transfer agent

Up

1.70 ± 0.36*

 bab_RS27050

Hrp-dependent Type III effector

Up

1.26 ± 0.13

 bab_RS23095

Predicted membrane protein (DUF2306)

Up

1.23 ± 0.20

 bab_RS31525

Hypothetical protein

Up

1.20 ± 0.35

 bab_RS22085

Hypothetical protein

Down

0.76 ± 0.23

 bab_RS27055

Hypothetical protein

Down

0.76 ± 0.12

  1. Statistical significance was determined using two-tailed Student’s t test.
  2. *p < 0.05.