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Figure 7 | Veterinary Research

Figure 7

From: Preferential use of Siglec-1 or Siglec-10 by type 1 and type 2 PRRSV strains to infect PK15S1–CD163 and PK15S10–CD163 cells

Figure 7

GP5 ectodomain amino acid and N-glycosylation site analysis for both type 1 and type 2 PRRSV strains. A graphic representation of an amino acid sequence alignment of the GP5 ectodomain, starting with the 1st amino acid (aa) at the plasma membrane. The potential glycosylation sites were indicated with colored boxes. The first N glycosylation site is N10 which is 10 aa away from the membrane (indicated with grey boxes). The second N-glycosylation site N17 is colored blue. The third or fourth N-glycosylation sites at N26/N27 is colored green, N28 is colored with purple and at N31 is colored with red. Black arrows represent the signal peptide cleavage site for GP5 protein. The virus strains were ranked on the infection rate in Siglec-1 expressing cells. The ranking is represented with a heat map (Red represent a low percentage, yellow represents a medium percentage and green represent high percentage). The preferences for Siglec-1 and Siglec-10 were indicated with an infection ratio of S1/S10 or S10/S1.

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