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Table 7 Differential expression profile of alternative Fc receptors in peritoneal exudate cells from cats with FIP compared to peritoneal cells from healthy cats

From: Characterization of peritoneal cells from cats with experimentally-induced feline infectious peritonitis (FIP) using RNA-seq

Gene

Ligand

Cell distribution

Effect following binding to antibody

Log2FC

P adjusted

FcγRIIA (CD32)

IgG

Macrophages neutrophils eosinophils, DC, platelet

Phagocytosis, degranulation eosinophils

ND

 

FcγRIIB1 (CD32)

IgG

B cells mast cells

No effect on phagocytosis, inhibition of cell activity

1.03

0.011

FcγRIIIA (CD16a)

IgG

B-cell, NK cells, neutrophils, macrophages, FDC

Induction of ADCC, cytokine release by macrophage

2.32

8.20E−10

FcγRIIIB (CD16b)

IgG

Eosinophils macrophages neutrophils mast cells follicular dendritic cells

Induction microbe killing

ND

 

FcεRI

IgE

Mast cells, monocytes, eosinophils basophils langerhans cells

Degranulation eosinophils, phagocytosis

ND

 

FcεRII (CD23)

IgE

B cells, eosinophils. Langerhan cells

Allergic sensitization, IgE transport

0.93

0.237

FcαRI (CD89)

IgA

Monocytes macrophages neutrophils, eosinophils

Phagocytosis, microbe killing

ND

 

Fcα/μR

IgA, IgM

B cells, mesangial cells, macrophages

Endocytosis, induction microbe killing

0.88

0.44

FcRn (FCGRT)

IgG

Monocytes macrophages dendritic cells epithelial cells endothelial cells

Maternal IgG transfer placenta and milk, protects IgG from degradation

−0.54

0.200

  1. Genes in italics were significantly up-regulated. Several RNAs were not detected (ND).