Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate

Table 3 Transmission of the CH1641-like scrapie isolate (Sh294) to TgBoPrP mice

Source	Recipient	Passage #	Survival period^a	n/n ^b_o
Sh294 brain (CH1641-like Scrapie)	TgBoPrP	3	172 ± 4.5*	11/11
Cattle L-BSE brain	TgBoPrP	3	144 ± 4.8*	12/12
Cattle C-BSE brain	TgBoPrP	3	195 ± 4.6	14/14
Cattle H-BSE brain	TgBoPrP	3	220 ± 4.3	11/11

^aSurvival periods are shown as mean survival days ± standard deviation.
^bNumber of PrPres-positive mice out of the total number of challenged mice. All inoculated mice showed unique clinical signs of the disease (Sh294 and L-BSE, circling behavior; C-BSE, head twitching; H-BSE, constant chewing of the bedding).
* P < 0.0001.

ISSN: 1297-9716