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Figure 2 | Veterinary Research

Figure 2

From: Understanding the mechanisms of viral and bacterial coinfections in bovine respiratory disease: a comprehensive literature review of experimental evidence

Figure 2

Heat map showing the impact of sequential coinfections on respiratory pathology in cattle on in vivo experiments. On the y-axis, the virus used for the primary viral infection is represented. On the x-axis, the pathogen used for the secondary superinfection is listed. The severity of coinfections on in vivo studies (compared to single pathogens) was given a score from 1 to 4 (colour code for the score is given in function of the increase in clinical signs, light orange to dark orange). The description of the scoring system that we used to describe the impact of coinfection in vivo is available as Additional file 1. Cell values represent the mean between the scores given to different in vivo studies performed with the same pathogens. The value in parentheses represents the number of trials carried out for each couple of pathogens that were used to calculate the mean score. White cells indicate an absence of in vivo studies for that specific couple of pathogens. *: the two pathogens were simultaneously inoculated in some studies.

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