Figure 9
CUR improves brain congestion, changes in organ indices, and vascular cuffing in PRV-infected rats. Rats were intraperitoneally injected with low, medium, and high doses of CUR or 0.5% sodium carboxymethylcellulose solution (the solvent of CUR) for 7 consecutive days, and on the 8th day, the rats were intraperitoneally injected with/without PRV. On the 14th day (7 dpi), the rats in each group were sacrificed by decapitation, and the brain tissue was harvested for imaging to evaluate the organ index and prepare pathological sections. A The degree of blood congestion in the brain tissue in each group (n = 3). B Changes in the viscera index in rat brain tissue (n = 3). C Pathological sections of the cortex in each group, a: Control group, b: PRV group, c: CUR L group, d: CUR M group, e: CUR H group (n = 3), scale bar = 20 μm. All experiments were performed in parallel. The results are presented as the mean ± SD. Statistical significance was determined using one-way ANOVA followed by an LSD post hoc test for multiple comparisons among the groups. *P < 0.05, **P < 0.01, ***P < 0.001, and NS, not significant.