Figure 7
From: Monoclonal antibody specific to HA2 glycopeptide protects mice from H3N2 influenza virus infection
Characterization of IFN-γ and TNF-α secretion from lung tissues of mice challenged with virus. Cytokine concentrations were measured by ELISA in supernatants of homogenates from the lungs infected with three virus strains. Mice were pretreated with 20 mg/kg of mAb D7, mAb IgG or PBS 1 day before challenged with virus JS/10 (A, D), GD/12 (B, E) or SD/05 (C, F), respectively. The cytokine levels were measured in the infected mice on days 2, 4, 6, 10 and 14 post challenged. The results are expressed in terms of pg/mL. *P < 0.05, or **P < 0.01 indicates significantly different changes for mAb D7 group compared with the virus-infected group or the mAb IgG group. # P < 0.05, or ## P < 0.01, indicates a significant difference between this group and the PBS control group.