Upstream regulator | High responders | Low responders |
|---|
Activation z-score |
P value of overlap | Activation z-score |
P value of overlap |
|---|
TNF | −3.4 | 4.93E-09 | −5.9 | 1.86E-25 |
Lipopolysaccharide (LPS) | −3.3 | 5.27E-10 | −6.0 | 4.09E-32 |
IL1B | −2.8 | 1.81E-09 | −5.2 | 1.08E-28 |
NFkB (complex) | −2.7 | 4.98E-08 | −4.5 | 1.32E-15 |
Mma_DMAG | −2.6 | 2.12E-12 | −3.9 | 6.94E-20 |
Immunoglobulin | −2.5 | 1.56E-09 | n/a | n/a |
IFNG | −2.4 | 1.28E-06 | −4.4 | 3.36E-20 |
Salmonella enterica-LPS | −2.4 | 1.66E-08 | −3.1 | 1.61E-12 |
poly rI:rC-RNA | −2.4 | 2.11E-06 | −4.3 | 1.20E-16 |
E. coli B5-LPS | −2.3 | 1.53E-07 | −4.1 | 1.33E-16 |
STAT3 | n/a | n/a | −4.0 | 1.82E-16 |
IL1A | n/a | n/a | −3.9 | 2.49E-22 |
- Data with P value < 0.05 and ¦activation Z-score¦ ≥2 were considered significant. Information related to this table can be complemented by data reported by Additional file 4 which shows target molecules of the whole datasets and associated mechanistic pathway.
- Mma_DMAG, 5-O-mycolyl-beta-araf-(1→2)-5-O-mycolyl-alpha-araf-(1→1′)-glycerol [55]; n/a, not applicable (not found in the dataset). The P value of overlap, which indicates possible upstream regulators, represents the significance of the overlap between the dataset genes identified and the known targets of transcriptional regulators. The activation z-score was used to infer the state of activation of upstream regulators based on a comparison with a model that assigns random regulations.
