Table 1 The DEG listed involved in the pattern recognition receptor pathway and Jak-STAT signaling pathway in ALV-J-infected MDM

Pattern recognition receptor pathway ① Toll-like receptor signaling pathway; ② NOD-like receptor signaling pathway; ③ RIG-I-like receptor signaling pathway; ④ Cytosolic DNA-sensing pathway

 ENSGALG00000007015

CD40

①

3.89259, –

3 hpi

 ENSGALG00000015474

CD80

①

1.74169, –

3 hpi

 ENSGALG00000011389

TRAF3

①, ③

3.76105, –

3 hpi

 ENSGALG00000007932

TRAF6

①, ②, ③

1.27085, –

3 hpi

 ENSGALG00000009014

TRAF2

③

2.74956, 1.13451

3 hpi and 36 hpi

 ENSGALG00000000951

CCL5

①, ④

4.20314, –

3 hpi

 ENSGALG00000013356

IKBKE

①, ③, ④

2.38933, 1.06398

3 hpi and 36 hpi

 ENSGALG00000014297

IRF7

①, ③, ④

4.51047, –

3 hpi

 ENSGALG00000000534

IL1β

①, ②, ④

8.57939, –

3 hpi

 ENSGALG00000011668

K60 (IL8L1)

①, ②, ③

7.00993, –

3 hpi

 ENSGALG00000026098

IL8 (IL8L2)

①, ②, ③

5.96016, 1.67045

3 hpi and 36 hpi

 ENSGALG00000008612

MAPK11(p38Beta)

①, ②, ③

1.56955, –

3 hpi

 ENSGALG00000004735

MAP2K3(MKK3)

①

1.62121, –

3 hpi

 ENSGALG00000007356

MAP3K8

①

3.52264, –

3 hpi

 ENSGALG00000012304

NFKB1

①, ②, ③, ④

3.76626, –

3 hpi

 ENSGALG00000003428

PIK3R2

①

1.30282, –

3 hpi

 ENSGALG00000021573

PIK3R5L

①

2.7941, 1.12565

3 hpi and 36 hpi

 ENSGALG00000026167

PIK3R5

①

2.77632, 1.13829

3 hpi and 36 hpi

 ENSGALG00000001077

TIRAP

①

2.04202, –

3 hpi

 ENSGALG00000013861

TNFAIP3 (A20)

②

3.42548, –

3 hpi

 ENSGALG00000017186

BIRC2

②

3.67041, –

3 hpi

 ENSGALG00000007874

IL18

②, ④

2.72387, 1.6161

3 hpi and 36 hpi

 ENSGALG00000015899

RIPK2

②

4.27785, –

3 hpi

 ENSGALG00000021325

RIPK3

②

3.04709, –

3 hpi

 ENSGALG00000017485

TLR1A

①

–, 1.47044

36 hpi

 ENSGALG00000027093

TLR1B

①

–, 1.10129

36 hpi

 ENSGALG00000016590

TLR7

①

–, 1.15464

36 hpi

 ENSGALG00000008166

TLR15

2.10934, 1.89122

3 hpi and 36 hpi

 ENSGALG00000027864

NFKBIA

2.10466, 1.14704

3 hpi and 36 hpi

 ENSGALG00000005653

NFKB2

2.8071, 1.41077

3 hpi and 36 hpi

Jak-STAT signaling pathway

 ENSGALG00000002260

CISH (CIS)

2.58373, –

3 hpi

 ENSGALG00000003282

STAT5B

1.29572, –

3 hpi

 ENSGALG00000007158

SOCS1

4.22098, –

3 hpi

 ENSGALG00000027786

SOCS3

4.08564, 3.14348

3 hpi and 36 hpi

 ENSGALG00000010016

SOCS5

−1.07644, –

3 hpi