Amino acid changes in swine H1avN2 strains | Reported effectsb | Frequency of amino acid change in human or swine strains available in IRDa | |||||||
---|---|---|---|---|---|---|---|---|---|
NY/55/01 | A-11 | A-12 | B-14 | A-16 | Human 1957–1980 (N = 323) | Human 2000–2005 (N = 1921) | Human 2011–2016 (N = 8108) | Swine 2011–2016 (N = 4397) | |
T19 | A | A | A | A | – | 0.31 | 6.98 | 0.04 | 4.82 |
L23 | F | F | F | F | – | 0.31 | 47.11 | 98.87 | 5.53 |
A27 | V | V | V | V | – | 0 | 0.57 | 0.037 | 0.32 |
Y40 | H | H | H | H | – | 39.01 | 22.12 | 0.54 | 76.64 |
N47 | T | T | T | I | – | 0 | 0 | 0 | 1.07 |
A56 | T | I | I | I | – | 2.48(T)/97.21 (I) | 97.19(T)/0.10 (I) | 99.68(T)/0.19(I) | 93.43(T)/4.21(I) |
V66 | – | – | M | M | – | 0.31 | 0 | 0.11 | 0.86 |
E199 | – | – | – | K | – | 80.80 | 61.84 | 99.46 | 37.89 |
K221 | N | N | N | N | Antigenic drift/escape mutant | 99.69 | 1.04 | 0.78 | 81.49 |
K249 | R | R | R | R | – | 97.83 | 1.09 | 0.47 | 12.05 |
I254 | V | V | V | V | – | 0.31 | 0 | 0.30 | 1.02 |
V263 | – | – | I | I | – | 0.31 | 2.97 | 0.60 | 57.90 |
S271 | N | N | N | N | – | 0 | 0.10 | 0.16 | 0.23 |
Q273 | H | H | H | H | – | 0 | 0.05 | 0.01 | 0.07 |
N329 | K | K | K | K | Antigenic drift/escape mutant, removes a potential N-glycosylation site | 0 | 0.05 | 0.78 | 0.18 |
H336 | R | – | – | – | – | 0 | 0.05 | 0.04 | 0.45 |
D339 | G | G | G | G | – | 0 | 0.21 | 0.37 | 0.18 |
N358 | H | H | H | H | – | 0 | 0 | 0 | 0.07 |
S372 | L | L | L | L | Antigenic drift/escape mutant | 0.31 | 2.03 | 98.00 | 81.74 |
G401 | – | – | D | D | – | 70.59 | 2.76 | 0.42 | 10.98 |
E432 | – | – | – | K | Antigenic drift/escape mutant | 0 | 0.16 | 0.15 | 1.55 |
I469 | M | M | M | M | – | 0 | 0.10 | 0.04 | 3.78 |