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Figure 14 | Veterinary Research

Figure 14

From: Trichinella spiralis dipeptidyl peptidase 1 suppressed macrophage cytotoxicity by promoting M2 polarization via the STAT6/PPARγ pathway

Figure 14

rTsDPP1 downregulated the expression of FcγR I (CD64) in macrophages and reduced the ability of ADCC to kill larvae. A CD64 expression in rTsDPP1-treated macrophages was measured by flow cytometry. B The mean fluorescence intensity of CD64+ macrophages. C qPCR assay of CD64 expression in rTsDPP1-treated macrophages. D Killing effect of anti-Trichinella antibody-mediated ADCC on NBL. rTsDPP1-treated macrophages and T. spiralis-infected mouse serum (1:100 dilutions) were used in the ADCC assay. The cytotoxicity was ascertained as the percentage of dead larvae to the total larvae observed in each test. *P < 0.05 compared to the PBS group.

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Veterinary Research

ISSN: 1297-9716