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Figure 15 | Veterinary Research

Figure 15

From: Trichinella spiralis dipeptidyl peptidase 1 suppressed macrophage cytotoxicity by promoting M2 polarization via the STAT6/PPARγ pathway

Figure 15

 A STAT6 inhibitor (AS1517499) and PPARγ antagonist (GW9662) restored the expression of rTsDPP1-suppressed CD64 and the cytotoxicity of macrophages. A After macrophages were cultured with AS1517499 or GW9662, the mRNA expression of CD64 was assessed by qPCR. B ADCC killing effects on T. spiralis NBL. Macrophages preincubated with a STAT6 inhibitor (AS1517499, 100 nM) or a PPARγ antagonist (GW9662, 10 µM) were again incubated with various proteins for 24 h. Cytotoxicity was calculated as the percent of dead NBL to total larvae observed in each assay. *P < 0.001 compared to the PBS group, # P < 0.001 between two groups.

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Veterinary Research

ISSN: 1297-9716