Table 4 Impact assessment of the non-synonymous V2G and V182I polymorphisms using Polyphen-2, PROVEAN, PANTHER, Meta-SNP and PredictSNP.
Polymorphism | Method | Score | Prediction |
|---|---|---|---|
c.5T>G (V2G) | PolyPhen-2 | 0.033 | Benign |
PROVEAN | 2.034 | Neutral | |
PANTHER | 97 | Possibly benign | |
Meta-SNP | 0.034 | Neutral | |
PredictSNP | 83(expected accuracy) | Neutral | |
c.544G>A (V182I) | PolyPhen-2 | 0.084 | Benign |
PROVEAN | −0.174 | Neutral | |
PANTHER | 220 | Possibly damaging | |
Meta-SNP | 0.26 | Neutral | |
PredictSNP | 60(expected accuracy) | Neutral |