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Table 2 Binding affinity of anti-PD-1 rabbit mAb and chAb to BoPD-1-His protein

From: Development of a high-affinity anti-bovine PD-1 rabbit–bovine chimeric antibody using an efficient selection and large production system

Anti-PD-1 antibody

ka (1/Ms)*

kd (1/s)*

KD (M)*

1D10F1

5.00 × 105 ± 0.29

6.17 × 10–4 ± 0.38

1.23 × 10–9 ± 0.05

Boch1D10F1

4.37 × 105 ± 0.09

6.13 × 10–4 ± 0.61

1.37 × 10–9 ± 0.09

  1. These values were measured on a Biacore 3000 instrument
  2. *The values of 1D10F1 and Boch1D10F1 are not significantly different (p > 0.05)
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Veterinary Research

ISSN: 1297-9716