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Figure 3 | Veterinary Research

Figure 3

From: Inter- and intra-species conversion efficacies of Norwegian prion isolates estimated by serial protein misfolding cyclic amplification

Figure 3

Amplification of Norwegian CWD and experimental classical scrapie isolates in sheep and goat substrates after 8 rounds of PMCA. A Only the reindeer and scrapie isolates were amplified in VRQ/VRQ and ARQ/ARQ sheep substrates. B Only the experimental classical scrapie isolate was amplified in goat Q220/L220 substrate. None of the isolates were amplified in the sheep brain with the most scrapie resistant genotype ARR/ARR and the goat Ter32/Ter32 substrate without expression of the cellular prion protein. VRQ/VRQ V136R154Q171/V136R154Q171, ARR/ARR A136R154R171/A136R154R171, Mo moose, C. scrapie experimental classical scrapie, kDa molecular weight in kilodalton.

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Veterinary Research

ISSN: 1297-9716