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Figure 4 | Veterinary Research

Figure 4

From: Inter- and intra-species conversion efficacies of Norwegian prion isolates estimated by serial protein misfolding cyclic amplification

Figure 4

Biochemical properties of the PMCA products by discriminating primary antibodies. The Sha31 antibody, recognizing the core region and the P4 antibody targeting the N-terminal of the PrPSc were used to assess the biochemical properties of the amplified products in A moose, B red deer, C reindeer and (D) roe deer substrates. The amplified PrPSc exhibited properties similar to those of the original isolates except for the reindeer isolate that lost the P4 epitope in the moose Q109/Q109 and K109/Q109 substrates. * Unspecific band; Mo moose. C. scrapie experimental classical scrapie, kDa molecular weight in kilodalton.

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Veterinary Research

ISSN: 1297-9716